Fulvic Acid Viral Diseases

Results showed that humic acid, when consumed before the virus invaded the body, was effective in presenting disease.

Scientific studies have demonstrated that if a host cell is penetrated before the introduction of the Humic/Fulvic Acid, the reproductive process is not halted. HOWEVER, after the virus reproduces, the host cell releases the new viruses into the bloodstream. At this point, if Humic/Fulvic Acid is present, it can prevent the new generation(s) of viruses from attaching to additional host cells. This is a therapeutic action that the above research has not specifically verified in procedure, hence the above conclusion. Further, the interaction of Humic/Fulvic Acid regarding the aforementioned viral studies would also be presumed to work for most if not all viral diseases. Other studies are currently on going throughout the world.

2002 National Institutes of Health (NIH) The NIH published a report titled “Broad Spectrum Antiviral Effectiveness of Humates”. The NIH studied humic acid’s virus-fighting properties for viral diseases such as gastroenteritis, influenza, herpes, chicken pox, mononucleosis and hemorrhaging fevers caused by the Ebola and Hanta viruses. Results showed that humic acid, when consumed before the virus invaded the body, was effective in presenting disease. Tests performed against multiple virus types further confirmed humic acids broad anti-viral properties. Toxicity tests showed that humic acid bound itself to human cells but was not itself toxic, nor did it inhibit or interfere with cell development or reproduction. 

Medical Aspects and Applications of Humic Substances” Regarding the Antiviral Activity of Humic Substances Prof. Dr. Renate Klocking & Dr. rer. nat. Bjorn Helbig Institute for Antiviral Chemotherapy, Friedrich Schiller University, Jena, Germany MULTIPLE VIRUSES INHIBITED “Preliminary in-vitro studies with Coxsackie A9 virus, influenza A virus and herpes simplex virus type 1 (HSV-1) have already shown that (Humic Substances) are effective against both naked and enveloped DNA viruses (Klocking and Sprosig, 1972, 1975; Thiel et al., 1977).” “Further investigations corroborate the ability of (Humic/Fulvic Acid) to inhibit selectively viruses for human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), cytomegalovirus (CMV) and vaccinia virus (Schols et al., 1991; Neyts et al., 1992).” VIRAL FUSION INHIBITION “With most viruses, the inhibitory effect of (Humic/Fulvic Acid) is directed specifically against an early stage of virus replication, namely virus attachment to cells (Klocking and Sprosig, 1975; Schols et al., 1991; Neyts et al., 1992).” “…it appears likely that the poly-anionic Humic/Fulvic Acids occupy positively charged domains of the viral envelope glycoprotein’s, which are necessary for virus attachment to the cell surface (Neyts et al., 1992).” HERPES “The effect of (Humic/Fulvic Acids) on an early stage of herpes virus replication has been confirmed by the results of animal experiments. The number of lesions in the cornea of HSV-1-infected rabbits was strongly reduced when a solution of the (Humic/Fulvic Acid) was applied into the conjunctival sac of the eye along with or immediately after the infectious agent.” “Current interest is directed to the prophylactic effect of (Humic/Fulvic Acids) on recurrent HSV infection.” “It is known that topical application of (Humic/Fulvic Acid) may significantly reduce or even completely suppress experimentally induced herpes in the mouse ear (Durre and Schindler, 1992), though the mechanistic basis of this effect remains to be elucidated.” HIV “A low-molecular weight (Humic/Fulvic Acid) (HS 1500, M.W. = 1500 Daltons), was found to strongly inhibit HIV-1 in vitro (Schneider et al., 1996).” NON-IRRITATING “Studies on the mechanism of action revealed virus penetration into host cells as the target of the anti-HIV-1activity. (Humic/Fulvic Acid) has passed a panel of pre-clinical tests including eye irritation according to Draize, as well as pregnancy risk in rats. Neither sensitizing nor irritating effects were detectable in concentrations of up to 10% HA/FA (Wiegleb et al., 1993; Lange et al., 1996a,b).’ 

Medical Aspects and Applications of Humic Substances” Regarding the Antiviral Activity of Humic Substances Prof. Dr. Renate Klocking & Dr. rer. nat. Bjorn Helbig Institute for Antiviral Chemotherapy, Friedrich Schiller University, Jena, Germany  https://goo.gl/ApT4Ks

MULTIPLE VIRUSES INHIBITED “Preliminary in-vitro studies with Coxsackie A9 virus, influenza A virus and herpes simplex virus type 1 (HSV-1) have already shown that (Humic Substances) are effective against both naked and enveloped DNA viruses (Klocking and Sprosig, 1972, 1975; Thiel et al., 1977).” “Further investigations corroborate the ability of (Humic/Fulvic Acid) to inhibit selectively viruses for human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2), cytomegalovirus (CMV) and vaccinia virus (Schols et al., 1991; Neyts et al., 1992).” 

VIRAL FUSION INHIBITION “With most viruses, the inhibitory effect of (Humic/Fulvic Acid) is directed specifically against an early stage of virus replication, namely virus attachment to cells (Klocking and Sprosig, 1975; Schols et al., 1991; Neyts et al., 1992).” “…it appears likely that the poly-anionic Humic/Fulvic Acids occupy positively charged domains of the viral envelope glycoprotein’s, which are necessary for virus attachment to the cell surface (Neyts et al., 1992).” HERPES “The effect of (Humic/Fulvic Acids) on an early stage of herpes virus replication has been confirmed by the results of animal experiments. The number of lesions in the cornea of HSV-1-infected rabbits was strongly reduced when a solution of the (Humic/Fulvic Acid) was applied into the conjunctival sac of the eye along with or immediately after the infectious agent.” “Current interest is directed to the prophylactic effect of (Humic/Fulvic Acids) on recurrent HSV infection.” “It is known that topical application of (Humic/Fulvic Acid) may significantly reduce or even completely suppress experimentally induced herpes in the mouse ear (Durre and Schindler, 1992), though the mechanistic basis of this effect remains to be elucidated.” HIV “A low-molecular weight (Humic/Fulvic Acid) (HS 1500, M.W. = 1500 Daltons), was found to strongly inhibit HIV-1 in vitro (Schneider et al., 1996).” 

NON-IRRITATING “Studies on the mechanism of action revealed virus penetration into host cells as the target of the anti-HIV-1 activity. (Humic/Fulvic Acid) has passed a panel of pre-clinical tests including eye irritation according to Draize, as well as pregnancy risk in rats. Neither sensitizing nor irritating effects were detectable in concentrations of up to 10% HA/FA (Wiegleb et al., 1993; Lange et al., 1996a,b).’ 

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Genetic diversity-independent neutralization of pandemic viruses (e.g. HIV), potentially pandemic (e.g. H5N1 strain of influenza) and carcinogenic (e.g. HBV and HCV) viruses and possible agents of bioterrorism (variola) by enveloped virus neutralizing compounds (EVNCs).

Recently, both fulvic acid and pomegranate juice have been shown to inactivate genetically diverse strains of influenza including H5N1, further confirming the broad spectrum nature of these agents.

https://www.ncbi.nlm.nih.gov/pubmed/18241960

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Interaction of humic acids and humic-acid-like polymers with herpes simplex virus type 1

This finding speaks in favour of the formation of antivirally active structures during the oxidative polymerization of phenolic compounds and, indirectly, of corresponding structural parts in different HA-type substances.

https://link.springer.com/chapter/10.1007/BFb0010491

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Inhibitory Effect of Fulvic Acid Extracted from Canadian Sphagnum Peat on Chemical Mediator Release by RBL-2H3 and KU812 Cells

Our results show that CP-FA may be useful for the treatment or prevention of allergic diseases.

https://www.jstage.jst.go.jp/article/bbb/advpub/0/advpub_60702/_article/-char/ja/

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In vitro anti-influenza virus activity of synthetic humate analogues derived from protocatechuic acid.

https://www.ncbi.nlm.nih.gov/pubmed/11890523

Two humic-like substances, the oxidative polymer of protocatechuic acid (OP-PCA) and humic acid inhibit the in vitro replication of influenza virus A/WSN/33 (H1N1) in Madin-Darby canine kidney (MDCK) cells at concentrations of no cytotoxicity. The 50% inhibitory concentration (IC50) for OP-PCA was 6.59 +/- 1.02 microg/ml when the compound was added at the stage of viral adsorption. When OP-PCA was added after virus adsorption, the IC50 was 53.27 +/- 8.12 microg/ml. The IC50 for humic acid was 48.61 +/- 7.32 microg/ml and 55.27 +/- 5.46 microg/ml respectively when the compound was added at the stage of viral adsorption or post-adsorption. In spite of structural resemblance of these two compounds, they exhibit different actions of anti-flu. The OP-PCA inhibits virus-induced hemagglutination and low pH-induced cell-cell fusion. Humic acid inhibits the endonuclease activity of viral RNA polymerase. The monomer of PCA shows no inhibition on influenza virus replication.

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In Vitro Studies of the Antiviral Activity of Ammonium Humate Against Herpes Simplex Virus Type 1 and Type 2; .

The study was performed in order to compare the antiviral activity against herpes simplex virus type 1 (HSV-1) of synthetic humic-acid-like polymers to that of their low-molecular-weight basic compounds and naturally occurring humic acids (HA) in vitro.

https://link.springer.com/chapter/10.1007/BFb0010491

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J. Schneider, et al; Inhibition of HIV-1 in Cell Culture by Synthetic Humate Analogues Derived From Hydroquinone: Mechanism of Inhibition; Virology 1996, 218(2), pp. 389-395. https://www.ncbi.nlm.nih.gov/pubmed/8610466

R. Mentel, et al; Effectiveness of Phenol Body Polymers Against Influenza Virus A/KRASNODAR/101/59/H2N2; Biomed Biochim Acta 1983, 42(10), pp. 1353-1356. https://www.ncbi.nlm.nih.gov/pubmed/6675676

J. Hills; et al; Inhibition of Several Strains of Influenza Virus Type A and B by Phenolic Polymers; Biomed Biochim Acta 1986, 45(9), pp. 1173-1179.

https://www.ncbi.nlm.nih.gov/pubmed/3814107

K.I. Hanninen, et al; Synthesis and Characterization of Humic Acid-Like Polymers; The Science of the Total Environment 1987, 62, pp. 201- 210.

https://www.researchgate.net/publication/229199215_Synthesis_and_characterization_of_humic_acid-like_polymers

R. Klocking et al.–Interaction of Humic Acids and Humic-Acid-Like Polymers with Herpes Simplex Virus Type 1 Humic Substances in the Aquatic and Terrestrial Environment New York; Springer-Verlag 1989, pp. 407-412.

https://www.ncbi.nlm.nih.gov/pubmed/12495212

D. Schols, et al; Selective Inhibitory Activity of Polyhydroxycarboxylates Derived From Phenolic Compounds Against Human Immunodeficiency Virus Replication; Journal of Acquired Immune Deficiency Syndromes 1991, 4(7), pp. 677-685. https://www.ncbi.nlm.nih.gov/pubmed/1675677

M. Cushman, et al; Synthesis and Anti-Hiv Activities of Low Molecular Weight Aurintricarboxylic Acid Fragments and Related Compounds; Journal of Medicinal Chemistry 1991, 34(1), pp. 337-342.

M. Robert Gero, et al; Biochemical Study of Humus Action of a Proteolytic Enzyme on Natural and Synthetic Humic Polymers and Those of Microbial Origin–Ann Inst Pasteur (Paris) Dec. 1967, 113(6), pp. 903-909.

M. Jakubiec; et al; Comparison of the Effect of Natural and Synthetic Humates and EDTA on the Growth of Escherichia coli; Abstract not available.

R. Ansorg; et al; Studies on the Antimicrobial Effect on Natural and Synthetic Humic Acids; Arzneimittleforschung 1978, 28(12, pp. 2195- 2198.