Protection against Gluten-mediated Tight Junction Injury with a Novel Lignite Extract Supplement
Naturally-oxidized lignite extracts including shilajit, humic acids and fulvic acids have been used as dietary supplements to deliver soil-based minerals and amino acids in China and India for hundreds of years.
Protective Effects of Lignite Extract Supplement on Intestinal Barrier Function in Glyphosate-Mediated Tight Junction Injury
Conclusion: The lignite extract supplement blocked a glyphosate-dependent decrease in TEER in both cell lines. If found efficacious in clinical trials, RESTORE could prove helpful in combating intestinal sensitivities caused by glyphosatemediated tight junction disruption.
Shilajit used for digestive disorders
Shilajit has been used for the treatment of hypersensitivity, diabetes, digestive disorder, nervous ailment, tuberculosis, chronic bronchitis, asthma, anemia,eczema, bone fractures, genitourinary ailment and many other diseases (17, 18). Fulvic acid is the main constituent of Shilajit and along with FA and HA it also contains minerals in ionic form. These minerals are transported to cells and tissues by fulvic acid, which maintains the electric potential of the cells of the body and thus possibly prevents its death, provides the longevity and might act as a rejuvenator. It helps in metabolism and energy production in the body. It can also act as detoxifying agent in the body and can function as immunomodulator and helps in haematopoiesis
Section 4: Gut Health
The gut forms the interphase of the outside world, the microbiome, and the host. Sufficient evidence shows that poor gut health can lead to inflammation and disease. In agriculture, FvA has been shown to influence the soil microbe composition and be able to conjugate itself to various minerals, aiding in the uptake in plants. As a result, FvA is suggested to improve the gut flora, nutrient absorption, and heal adverse disorders related to the gut
Figure 4: Known literature for the effects of fulvic acid on gut health. Fulvic acid has been shown to influence the microbiome, nutrient absorption, and gut disorders.